Women with resolved threatened preterm labour are at risk of progress into labour compared to normal population. Progesterone therapy has potential benefit to prolong the pregnancy by its effect in maintaining the uterine quiescence. This study aims to evaluate the role of progesterone therapy in women with resolved threatened preterm labour.

Method: This is a retrospective study, recruiting women presented with threatened preterm labour between June 2016 till April 2017. They consist of those who received progesterone therapy (N=19) and those who not (N=24) after the threatened preterm labour resolved. Gestation of delivery in both groups observed, with outcome of the babies born studied.

Result: Gestational age at delivery in intervention groups are lower than non intervention group (P=0.004), however duration of  pregnancy prolonged from time of threatened preterm labour in weeks, are longer in intervention group (P=0.002). Comparison of neonatal outcome shows no significant difference in NICU admission and complication of prematurity, however birth weight of the babies in intervention group appears lower than non intervention group (P=0.003).

Conclusion: Progesterone therapy in women with resolved threatened preterm labour is effective to prolonged pregnancy and improve neonatal outcome, as even though the birth weight and gestational delivery is lower than non intervention group the neonatal outcome is the same.