Introduction: Nephrogenic Diabetes Inspidus (NDI) is a clinical condition with polyuria and polydipsia. It resulted from insufficient production or end organ resistance to antidiuretic hormone (ADH). There are 2 types of DI i.e. central Diabetes Inspidus and Nephrogenic Diabetes Inspidus (NDI). The incidence of DI is 3 in 100,000 populations. Acquired NDI is the most common cause of NDI. These include kidney or systemic disorder.

Case Presentation: This is a case report of a 57 year old lady with pelvic organ prolapse. Her urine output ranges from 2,000 to 2,500 mls/day prior to surgery. Following pelvic organ prolapse surgery, her urine output ranges from 5,000 to 9,000 mls/day. Her urine osmality is low. She was monitored and her deficit was replaced. Her urine output stablilised after 3 days post surgery. She was discharged 1 week after surgery.

Conclusion: DI is a rare condition and NDI even rarer. Monitoring fluid post surgery is important. Adequate correction of electrolyte imbalance is important for patient wellbeing.