Introduction: In endometrial cancer, the depth of myometrial invasion (DOI) is the single most important determinant of nodal spread and disease recurrence. Thus, the ability to determine accurately the DOI will help us to decide on how extensive the surgical staging is going to be.

Objective: The objective of this preliminary study is to evaluate the accuracy of frozen section in determining the DOI as compared to the full histology. Besides that, we are also evaluating the accuracy of frozen section in determining the cervical stromal invasion

Materials and Methods: For all the cases of endometrial carcinoma undergoing surgery, the hysterectomy specimens were sent for intra-operative frozen section evaluation. We reviewed all the intra-operative frozen results and compared it with their corresponding full histology.

Results: We have a total of 14 cases of endometrial cancer in which intra-operative frozen section were performed. If the depth of myometrial invasion (DOI) reported as more or less than 50%, the positive predictive value (PPV) of a frozen section is 100.0% with the negative predictive value (NPV) of 77.8%. If the DOI of less than 50% further subdivided into less than 50% or no invasion, the PPV of drop down to 71.4% with the NPV of only 50%. We also look at the cervical stromal invasion on frozen section and the PPV for cervical stromal invasion is 100% with a NPV of 76.9%

Conclusion: The intra-operative frozen section has a reasonably good PPV and NPV to predict the DOI and cervical stromal invasion in endometrial carcinoma. In the centre where the facility for frozen section is available, it should be part of the assessment in women with endometrial carcinoma and the result should be used as guide to determine the extent of surgical staging.