Introduction: HIV-positive pregnant women need special care and management in order to prevent further transmission towards the fetus. Based on the Indonesian Ministry of Health Report in 2016, there were about 0.49% of pregnant women being HIV-positive, and it increases gradually each year. Antiretroviral treatment is required to be administered regardless to the stage of HIV, gestational age, CD4 or the viral load. However, there has been report of the side effect of Tenofovir as one of the regime that can cause deterioration of the kidney function. 

Method: Reporting a case report of a 21-years-old woman with HIV-positive and administer FDC (TDF/3TC/EFV). Kidney function test showed deterioration after 3 months consumption of daily FDC.

Result: Patient was referred from a rural hospital, due to the active stage of labor when the pregnancy was still 34 weeks. The laboratory result showed poor kidney function and she denied any consumption of other nephrotoxic drugs or complaints regarding to her micturition. Emergency C-section was performed, and a female baby weighed 1850 gram with AS 8-9 was born. The regime of Tenofovir was replaced and the kidney function test showed improvement after one month follow-up thereafter.

Discussion: Antiretroviral is required to be administered for all pregnant women regardless to their HIV staging and also their CD4 and viral load level. However, each ARV has their own side effect and it needs to be adjusted for certain patient.

Keywords: HIV-positive, pregnancy, acute kidney injury, Tenofovir